Mike,
Have you considered doing further testing static?
Syncing the carbs likely will not produce a positive result unless they were way way off.
Have you inspected the plugs - this is where you can tell what your fuel delivery condition is. White, sooty, dry, wet, black and on which plugs and where on the plug. It's the 1st thing I'd do before flying it!
Do you know what the CHT's and EGT's and RPM were just prior to the problem and what they were after the problem develops?
A rich condition can take some time to show as the engine heats up. I suspect that might be the case here.
Greg